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Stevens-Johnson syndrome
1 OMIM reference -
1 associated gene
42 signs/symptoms
COMMON GENES: 1
COMMON SIGNS: 7
Takayasu arteritis
1 OMIM reference -
3 associated genes
41 signs/symptoms
Stevens-Johnson syndrome
Takayasu arteritis

HLA-B
(UniProt - OMIM)
 HLA-B
(UniProt - OMIM)
IL12B
(UniProt - OMIM)
MLX
(UniProt - OMIM)

COMMON
GENES 		HLA-B


Citations in the biomedical literature:


Stevens-Johnson syndrome
HLA-B
Takayasu arteritis
IL12B MLX



Stevens-Johnson syndrome
Takayasu arteritis

Synonym(s):
- Dermatostomatitis, Stevens Johnson type
Synonym(s):
(no synonyms)
Classification (Orphanet):
- Rare skin disease
Classification (Orphanet):
- Rare circulatory system disease
- Rare renal disease
- Rare systemic or rheumatologic disease
Classification (ICD10):
- Diseases of the skin and subcutaneous tissue -
Classification (ICD10):
- Diseases of the musculoskeletal system and connective tissue -
Epidemiological data:
Class of prevalence: unknown
Average age onset: variable
Average age of death: -
Type of inheritance: sporadic
Epidemiological data:
Class of prevalence: 1-9 / 1 000 000
Average age onset: adulthood
Average age of death: -
Type of inheritance: sporadic
External references:
1 OMIM reference -
1 MeSH reference: D013262
External references:
1 OMIM reference -
1 MeSH reference: D013625
COMMON
SIGNS 		- Anaemia
- Angor pectoris / myocardial infarction
- Asthenia / fatigue / weakness
- Chronic uveitis / blepharitis / episcleritis / scleritis / conjonctivitis / keratitis
- Fever / chilling
- Visual loss / blindness / amblyopia
- Weight loss / loss of appetite / break in weight curve / general health alteration

Stevens-Johnson syndrome
Takayasu arteritis

Very frequent
- Enanthema / aphtosa / aphta / leukoplakia
- Erythema / erythematous lesions / erythroderma / polymorphous erythema
- Macules
- Malabsorption / chronic diarrhea / steatorrhea
- Nausea / vomiting / regurgitation / merycism / hyperemesis
- Positive Nikolski's sign / achantolysis
- Vesicles / bullous / exsudative lesions / bullous / cutaneous / mucosal detachment

Frequent
- Feeding disorder / dysphagia / swallowing / sucking disorder / esophageal dyskinesia
- Hypersialorrhea
- Polynuclear cells / neutrophils anomalies / neutropenia

Occasional
- Abnormal hepatic enzymes / transaminases
- Abnormal pleura / hydrothorax / pleuresia / pleural effusion / chylothorax
- Acute abdominal pain / colic
- Acute hepatic failure
- Collapse / sudden death / cardiac arrest / cardiorespiratory arrest
- Corneal ulceration / perforation
- Cough
- Dyspareunia / coital pain / vaginal dryness
- Ectropion / entropion / eyelid eversion
- Gastroesophageal reflux / pyrosis / esophagitis / hiatal hernia / gastroparesia
- Gastrointestinal bleeding / hemorrhage / hematemesis / melena / rectorrhagia
- Interstitial / restrictive pneumopathy / restrictive respiratory syndrome
- Intestinal perforation
- Myocardium anomalies / myocarditis
- Pancreatitis
- Phimosis / preputial adhesions / paraphimosis
- Photophobia
- Pollakiuria / polyuria / dysuria / anuria / acute urine retention / oliguria
- Renal failure
- Repeat respiratory infections
- Respiratory distress / dyspnea / respiratory failure / lung volume reduction
- Sepsis severe / septicemia
- Thirst
- Thrombocytopenia / thrombopenia
- Urethral anomalies / stenosis / posterior urethral valves / megalocystis


Very frequent
- Acute arterial hypertension / hypertensive crisis
- Acute ischemic syndrome
- Arterial aneurism (excluding aorta)
- Arterial pulse abolition
- Arterial stenosis / occlusion
- Cardiac valvulopathy
- Hyperhidrosis / increased sweating
- Subcutaneous nodules / lipomas / tumefaction / swelling
- Vascularitis / vasculitides / arteritis

Frequent
- Anorexia
- Aortic root dilatation / dilation / aneurysm
- Aortic valve atresia / stenosis / narrowing / supra-aortic / supra-valvular stenosis
- Arthritis / synovitis / synovial proliferation
- Biological inflammatory syndrome / increased erythrocyte sedimentation rate / CRP
- Cardiomyopathy / hypertrophic / dilated
- Chronic arterial hypertension
- Chronic skin infection / ulcerations / ulcers / cancrum
- Facial pain / cephalalgia / migraine
- Gangrena / necrosis
- Muscle weakness / flaccidity
- Myalgia / muscular pain
- Pulmonary hypertension
- Respiratory rhythm disorder
- Seizures / epilepsy / absences / spasms / status epilepticus
- Thoracic / chest pain

Occasional
- Articular / joint pain / arthralgia
- Endocardium anomalies / fibroelastosis / endocarditis
- Hemoptysis
- Mesenteric / intestinal infarction
- Obnubilation / coma / lethargia / desorientation
- Retinopathy
- Speech troubles / aphasia / dysphasia / echolalia / mutism / logorrhea / dysprosodia
- Transient amaurosis / acute visual trouble
- Transient cerebral ischemia / stroke